Real Madrid tied AC Milan in the fourth leg of the Champions League thanks to Vinicius's penalty success in the first half but conceded two goals in a row, ultimately losing 1-3.
Manchester City, which is seeking its fifth consecutive win in English professional football, also lost heavily to Portugal Sporting.
Sporting, led by Amorim, Manchester United's next head coach, won the home game 4-1 against Manchester City.
Sporting continued their upward trend with three wins and one draw and Manchester City suffered their first Champions League defeat this season.
Liverpool, which leads English professional football, defeated Leverkusen, which won unbeaten German professional football last year, 4-0.
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